Diving for Cures

  • Researchers are hoping to find cures underwater in corals and sponges. (Photo courtesy of NOAA)

Making medicine from things
found in nature isn’t a new
idea. Think, aspirin – which
originally came from the bark
of willow trees. Now drugs
derived from ocean animals are
slowly making their way onto
shelves. Samara Freemark talks to a researcher
who helps get them there:

Transcript

Making medicine from things
found in nature isn’t a new
idea. Think, aspirin – which
originally came from the bark
of willow trees. Now drugs
derived from ocean animals are
slowly making their way onto
shelves. Samara Freemark talks to a researcher
who helps get them there:

Mark Slattery is trying to find a cure for cancer. Slattery is a pharmacology professor at the University of Mississippi. But he doesn’t really spend much time in the lab. Instead, he’s usually in a wetsuit, scuba diving off the coasts of places like Guam and Antarctica.

He’s taking samples from tens of thousands of corals and sponges. He’s looking for that one special species that might make a chemical that could cure disease. He calls it, ‘diving for cures.’

“In many ways, it’s like going out and playing your super lotto or whatever. You pick your eight numbers and you see if you hit or not.”

The idea is pretty simple. A third of the medicines on shelves today were derived from plants and animals that live on land. So ocean researchers got to thinking that the organisms they studied probably also produced a lot of useful chemicals.

Take corals and sponges. They can’t run away from predators, so instead they squirt out chemicals that poison the fish that try to take a bite out of them. Marc Slattery says those toxins are bad for the fish – but they could be good for people.

“Those particular compounds that tell a fish “not today” are the same ones that might tell the AIDS virus “you can’t replicate” or tell a cancer cell “you’re dead” or those kinds of things.”

So Slattery and other researchers like him clip off bits of sponges and corals. When they get back to the lab they extract the chemicals, which is a nice way of saying…

“Stick it in a blender with methanol and ethyl acetate and hexanes and all those sorts of things you used in organic chemistry lab, and you throw away the dead sponge, and the tarry residue that’s left is sort of the biochemistry that came out of that sponge.”

“So you make a sponge smoothie?”

“Exactly.”

Once they’ve extracted the chemicals, researchers test to see if they have any human application. If a compound looks promising, it moves on to clinical trials. Those trials can take decades, which is why ocean-derived drugs are only now starting to hit the market. So far only two have been approved for use in the United States: a painkiller, and a cancer drug marketed by Johnson and Johnson.

I wondered how ocean conservationists felt about diving for cures. So I called up Sandra Brooke. She studies corals at the Marine Conservation Biology Institute. Brooke says she does worry that diving for cures could lead to over-harvesting.

“Once something becomes valuable to people, there’s a resistance to closing access to it. It becomes harder to regulate it.”

But she says corals are under much greater and much more immediate threats. The biggest culprit is industrial trawling. That’s when fisherman scrape reefs off the ocean floor so they can get to the fish.

“It’s just like the clear cutting of the forest, but on a much vaster scale. They are deliberately mowing down these deepwater coral ecosystems that are thousands and thousands of years old – some of the oldest animals ever measured. And that’s not going to come back – not in our lifetimes, not in many lifetimes.”

There’s also the fact that oceans are changing as the climate does. Those changes mean corals are becoming weaker. Marc Slattery thinks he might be seeing that in a Pacific reef he’s been studying for fifteen years.

“When we went back and started looking at it, we noticed that there was a change in the chemistry through time. As things have heated up on the reefs, there’s a physiological effect that has cascaded down into their ability to produce the chemistry we’re used to seeing. Early on it was so apparent, it was always there, and now they seem to be able to produce less of it.”

That’s means that today the cure for cancer might be out there in some coral reef, but it could be gone tomorrow.

For The Environment Report, I’m Samara Freemark.

Related Links

Could Humans Get Chronic Wasting Disease?

  • A deer wasting away from Chronic Wasting Disease. (Photo courtesy of Michigan's Department of Natural Resources.)

A disease that infects deer and elk has been alarming wildlife officials and hunters for years. But now it seems the disease could be more dangerous than previously thought. The Great Lakes Radio Consortium’s Christina Shockley reports:

Transcript

A disease that infects deer and elk has been alarming wildlife officials
and hunters for years, but now it seems the disease could be more
dangerous than previously thought. The Great Lakes Radio Consortium’s
Christina Shockley reports:


Chronic Wasting Disease, or CWD, affects the brain tissue of deer and
elk. Sponge-like holes form in the brains of sick animals. The deer
begin to waste away, become weak, and then die.


Since CWD was discovered in Colorado nearly forty years ago, wild deer
in nine other states have tested positive for the disease. Little is known
about CWD – including how to stop it.


What scientists do know is that the infectious proteins-called prions –
thought to cause CWD are found in the brain and spinal cord areas of
infected animals, but officials still don’t have the answer to the big
question.


Judd Aiken is a professor of Animal Health and Biomedical Sciences at
the University of Wisconsin.


“The ultimate question is whether venison from infected animals, CWD infected
deer, poses a risk to humans. Clearly the first question that needed to be
asked and addressed was whether there was infectivity in muscle.”


Recent findings say there is.


Researchers at the University of Kentucky injected muscle from an
infected deer into the brains of genetically altered mice. The mice
displayed signs of CWD. This is the first time the infectious proteins
blamed for CWD have been found in deer meat.


The finding raises questions about whether eating venison is safe.
Researchers including Aiken say the study is important, but has limits.
For example, he says it doesn’t replicate what would happen in real life.
Plus, he says it’s probably unlikely humans can even get CWD. He says
studies suggest it’s difficult for the disease to jump to other species. Still,
he urges caution. Hunters should get the meat tested before they eat deer
from an area where CWD has been found.


“I, in no way, can advocate the consumption of infected deer, and indeed,
I would suggest due to the limitations of the CW tests, I don’t advocate
the consumption of deer obtained from a CWD endemic area.”


Even if the test comes back negative, Aiken says a negative result isn’t
always accurate, and infected animals in the beginning stages of the
disease can look and act normal.


(Sound of sporting goods store)


John White is a deer hunter from Sheboygan, Wisconsin. He’s in the
hunting section of a nearby sporting goods store. White isn’t too
concerned about Chronic Wasting Disease.


“Not a whole lot of people are worried about it. I mean, when it first
came out, some people were a little leery about it and didn’t want to hunt
that year, but they kinda got over it. I’m not really worried about it being
in the meat at all, because by the time the test comes back I’ll probably
have the deer eaten already and then it’s already too late.”


State wildlife officials say… that’s not a good idea. They recommend that
if you hunt deer in areas where the disease has been found, get the deer
tested before eating it. That message hasn’t changed… since learning the
prions could be in the meat. Some argue… it should change.


John Stauber is with a government watchdog group in Wisconsin, and
is co-author of “Mad Cow USA: Could the Nightmare Happen Here?”
He says officials are keeping quiet about the risk of CWD so they don’t
lose revenue from hunting licenses.


A large portion of state conservation agency budgets are dependent on
fees from hunting licenses. He says all deer that die should be tested for
the disease. Stauber also says CWD is a major human health concern.


“The biggest risk might not be the people who would die from
eating venison, but rather, the people who would die from the
contamination of the blood supply. This is a problem that would unfold
not in days or months or years, but even over decades.”


Stauber says it’s just a matter of time before Chronic Wasting Disease
spreads to people… he says some might even have the disease already,
and not know it.


But researchers like Judd Aiken from the University of Wisconsin say
people shouldn’t over-react.


“People should be concerned, but I don’t want people to panic, either. If
you think you may have consumed venison from infected animals, I don’t
think it’s likely that you’ll ever develop a human prion disease.”


But, Aiken says there’s too much we don’t know about the disease, and
since studies can take years to complete, we might be in the dark for a
while longer.


For the GLRC, I’m Christina Shockley.

Related Links

Ten Threats: Concrete Shores

  • Hardened shorelines protect buildings, roads, and homes, but many developers say a more natural method should be used. (Photo by Lester Graham)

Along many Great Lakes cities, long concrete or stone seawalls protect property against
wind and wave erosion. It’s a hardening of the shoreline that some people say is
necessary to protect expensive real estate. But some scientists and environmentalists say
it’s part of one of the ‘Ten Threats to the Great Lakes. They’re worried those concrete
seawalls are not only hurting the environment… in the long run, they’re hurting the
economy. Lynette Kalsnes has this report:

Transcript

In our series ‘Ten Threats to the Great Lakes,’ we’ve been looking at how humans make
changes that affect the health of the lakes. Lester Graham is our guide through the series.
He says the next report shows how far we’ll go to try to manage nature:


Along many Great Lakes cities, long concrete or stone seawalls protect property against
wind and wave erosion. It’s a hardening of the shoreline that some people say is
necessary to protect expensive real estate. But some scientists and environmentalists say
it’s part of one of the ‘Ten Threats to the Great Lakes. They’re worried those concrete
seawalls are not only hurting the environment… in the long run, they’re hurting the
economy. Lynette Kalsnes has this report:


(waves lapping against concrete wall)


In the middle of a miles-long concrete shoreline, there’s a tiny beach. Steve Forman points
toward a small bluff at the base of a tree. The professor of earth and environmental sciences at
the University of Illinois at Chicago says the sand, grass and dunes help soften the impact of
waves and rain.


“This kind of relief is what you’d see in many natural coastlines, a coastline like this can
accommodate change better than one that’s been concreted up.”


Just feet away, the concrete picks back up, like a stark white runway that bisects the land and the
lake. Concrete revetments like these in Chicago are a familiar sight in urban areas across the
Great Lakes.


Roy Deda is with the U.S. Army Corps of Engineers. The Corps manages much of the
construction on public shorelines. Deda says hardening the shore is one way of protecting against
erosion.


“Where hardening of the shoreline is important and used, is where you have an existing
community in an urban area like Chicago. You have a lot of development in place already, and
basically you’re protecting what’s been built over a long history.”


Deda says it protects property. But scientist Steve Forman says using concrete walls comes at a
cost: the destruction of natural systems that are often helpful.


Forman says wetlands and stream valleys normally act like a sponge to absorb high lake levels.
They also release some of the water back when lake levels are low. Forman says concrete can’t
buffer those fluctuations.


“It makes the extremes potentially even more extreme in terms of lake level variations.”


So, when there’s a rainstorm, Forman says the water runs off the concrete quickly… instead of
being absorbed across sand or wetlands slowly.


He says the same thing is true for the water flowing into the lakes from rivers.


Discharge into rivers can go up by 50 times the amount it would if natural areas buffered the
rivers.


“Any time we change the landscape from its natural components, we also change the plumbing of
the Great Lakes. We change the way water is routed in and around and through the Great Lakes
as well.”


It’s not only rushing rivers and lake levels that cause problems.


When the shoreline is hardened… the wildlife and organisms that once lived there disappear.


Cameron Davis is with the Alliance for the Great Lakes. He says many rare species live in that
narrow ribbon where the land meets the water.


“When we harden the shorelines, we basically sterilize them in a lot of ways, because we’ve not
providing the kinds of habitat and cover that we need for many of them.”


And beyond the effect on wildlife… hardening the shoreline can also be a bad economic decision.


Steve Forman says permanent structures built near the shores are not as stable as they might seem
when lake levels are high and winter storms cause big waves that erode the land underneath them.


“When the lake levels go up, the erosion rates are just phenomenal…what you see are hanging
stairs everywhere, instead of stairs that take you down to the beach, they’re hanging over the lake,
basically.”


That’s why scientists and planners are taking action. The Alliance for the Great Lakes’ Cameron
Davis is calling on planners to balance protecting the shoreline … with preserving ecology.


“Frankly I don’t think shoreline planning across the region is that great. There really is no single
unifying policy we’re all using to guide what our shorelines ought to look like.”


He’s hoping that some cities will experiment with restoring natural areas along their shorelines…
He says we need to see if in the long run, nature can do a better job of protecting the shores.


For the GLRC, I’m Lynette Kalsnes.

Related Links

Algae Mops Up Heavy Metals

The Great Lakes suffer from all kinds of pollution, but among the most dangerous pollutants from industrial waste are mercury, cadmium, and zinc. Researchers at Ohio State University are perfecting a way to clean up those heavy metals…. using algae. The Great Lakes Radio Consortium’s Bill Cohen explains:

Transcript

The Great Lakes suffer from all kinds of pollution, but among the most dangerous pollutants from industrial waste are mercury, cadmium, and zinc. Researchers at Ohio State University are perfecting a way to clean up those heavy metals – using algae. The Great Lakes Radio Consortium’s Bill Cohen explains:

Picture using algae as a sponge. The one-cell
plants attach themselves to the polluting metals…you pull them out of the
water…squeeze out the metals in an acid solution….and re-use the algae
sponge 30 times. Researcher Richard Sayre has genetically altered the
algae to sop up more pollution than ever:


“We’ve improved their ability to sequester and bind these heavy metals by a factor of five.”


Sayre stresses – the algae itself won’t be put
into the lakes free-floating …and it won’t even be living.


“The metal-binding capacity is about three times greater when they’re dead than when they’re alive.”


The next step for Sayre…convincing a few cities to let him put this algae into pollution control equipment so he can prove to them it’s a cheap and effective way to stop industrial waste before it gets into waterways.


For the Great Lakes Radio Consortium, I’m Bill Cohen.