Diving for Cures

  • Researchers are hoping to find cures underwater in corals and sponges. (Photo courtesy of NOAA)

Making medicine from things
found in nature isn’t a new
idea. Think, aspirin – which
originally came from the bark
of willow trees. Now drugs
derived from ocean animals are
slowly making their way onto
shelves. Samara Freemark talks to a researcher
who helps get them there:

Transcript

Making medicine from things
found in nature isn’t a new
idea. Think, aspirin – which
originally came from the bark
of willow trees. Now drugs
derived from ocean animals are
slowly making their way onto
shelves. Samara Freemark talks to a researcher
who helps get them there:

Mark Slattery is trying to find a cure for cancer. Slattery is a pharmacology professor at the University of Mississippi. But he doesn’t really spend much time in the lab. Instead, he’s usually in a wetsuit, scuba diving off the coasts of places like Guam and Antarctica.

He’s taking samples from tens of thousands of corals and sponges. He’s looking for that one special species that might make a chemical that could cure disease. He calls it, ‘diving for cures.’

“In many ways, it’s like going out and playing your super lotto or whatever. You pick your eight numbers and you see if you hit or not.”

The idea is pretty simple. A third of the medicines on shelves today were derived from plants and animals that live on land. So ocean researchers got to thinking that the organisms they studied probably also produced a lot of useful chemicals.

Take corals and sponges. They can’t run away from predators, so instead they squirt out chemicals that poison the fish that try to take a bite out of them. Marc Slattery says those toxins are bad for the fish – but they could be good for people.

“Those particular compounds that tell a fish “not today” are the same ones that might tell the AIDS virus “you can’t replicate” or tell a cancer cell “you’re dead” or those kinds of things.”

So Slattery and other researchers like him clip off bits of sponges and corals. When they get back to the lab they extract the chemicals, which is a nice way of saying…

“Stick it in a blender with methanol and ethyl acetate and hexanes and all those sorts of things you used in organic chemistry lab, and you throw away the dead sponge, and the tarry residue that’s left is sort of the biochemistry that came out of that sponge.”

“So you make a sponge smoothie?”

“Exactly.”

Once they’ve extracted the chemicals, researchers test to see if they have any human application. If a compound looks promising, it moves on to clinical trials. Those trials can take decades, which is why ocean-derived drugs are only now starting to hit the market. So far only two have been approved for use in the United States: a painkiller, and a cancer drug marketed by Johnson and Johnson.

I wondered how ocean conservationists felt about diving for cures. So I called up Sandra Brooke. She studies corals at the Marine Conservation Biology Institute. Brooke says she does worry that diving for cures could lead to over-harvesting.

“Once something becomes valuable to people, there’s a resistance to closing access to it. It becomes harder to regulate it.”

But she says corals are under much greater and much more immediate threats. The biggest culprit is industrial trawling. That’s when fisherman scrape reefs off the ocean floor so they can get to the fish.

“It’s just like the clear cutting of the forest, but on a much vaster scale. They are deliberately mowing down these deepwater coral ecosystems that are thousands and thousands of years old – some of the oldest animals ever measured. And that’s not going to come back – not in our lifetimes, not in many lifetimes.”

There’s also the fact that oceans are changing as the climate does. Those changes mean corals are becoming weaker. Marc Slattery thinks he might be seeing that in a Pacific reef he’s been studying for fifteen years.

“When we went back and started looking at it, we noticed that there was a change in the chemistry through time. As things have heated up on the reefs, there’s a physiological effect that has cascaded down into their ability to produce the chemistry we’re used to seeing. Early on it was so apparent, it was always there, and now they seem to be able to produce less of it.”

That’s means that today the cure for cancer might be out there in some coral reef, but it could be gone tomorrow.

For The Environment Report, I’m Samara Freemark.

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Drugs in the Water

  • There is some confusion about what to do with unused medications (Photo source: Shorelander at Wikimedia Commons)

The drugs we take are showing up in our drinking water, and they’re showing up in fish. The federal government’s now saying that in most cases, you should never flush unused drugs down the drain. There are safer ways to dispose of them. But even if you want to do the right thing, it’s not always easy. Rebecca Williams takes a look at what you should and should not do with your medications:

Transcript

The drugs we take are showing up in our drinking water, and they’re showing up in fish. The federal government’s now saying that in most cases, you should never flush unused drugs down the drain. There are safer ways to dispose of them. But even if you want to do the right thing, it’s not always easy. Rebecca Williams takes a look at what you should and should not do with your medications:

In the U.S., there are about 12,000 brand name and generic drugs on the market. And who knows how many over the counter drugs.

Scientists are finding many of these drugs in our water. Everything from caffeine, to allergy and anti-cancer drugs, to antidepressants.

Now, they’re finding these drugs at very low levels. But they’re pretty much everywhere.

An Associated Press investigation found trace amounts of pharmaceuticals in the drinking water of more than 40 million Americans.

“You know, we don’t think it’s enough to cause public harm but honestly nobody’s sure.”

That’s Sahar Swidan. She’s a pharmacist.

Right now, Swidan’s going through a five foot tall box of prescription drugs that people have brought to her store in Ann Arbor, Michigan. They might be expired, or just not needed anymore.

(sound of pill bottle shaking)


“Asthma medications, growth hormones for patients – so really the gamut could be anything and everything.”

A disposal company picks up the drugs about once a month and incinerates them.

Swidan’s drug take-back program is pretty rare. Many pharmacies are not set up to collect unused drugs.

One reason is, it takes a lot of work. Swidan has to sort through the drugs and make sure there aren’t any controlled substances – things like narcotics. It’s illegal for pharmacies to take these back in most cases.

The Drug Enforcement Agency is talking about revising their disposal rules for controlled substances. But for now you usually have to get rid of them yourself. So, how do you do that?

You can dissolve pills or caplets in water, and mix in kitty litter or coffee grounds. That’s to make the stuff look gross and undesirable. Then dump it all into ziptop bags, wrap it up in duct tape, and throw it away.

But to make things more complicated, there’s still a short list of drugs that you’re supposed to flush down the drain. The Food and Drug Administration says the drugs on this list are too dangerous to toss in the trash.

Connie Jung is with the FDA’s pharmacy affairs department. She says the drug label will tell you if you’re supposed to flush them.

“For the small number of prescription drugs that have flushing recommendations they have these because the drugs are strong narcotic pain relievers or other controlled substances. These drugs can be dangerous to those who aren’t supposed to be taking them, particularly children or pets.”

Jung says the FDA is currently reviewing disposal methods for these kinds of drugs… because flushing them down the toilet is starting to raise some questions.

An even bigger problem is that most of the drug residues getting into our water are coming from drugs we take and excrete.

Bryan Brooks is a researcher at Baylor University. He recently found low levels of seven drugs in fish caught near wastewater treatment plants. He says these sewer plants just can’t filter out drugs.

“These wastewater treatment facilities were largely not designed to treat to really ultra low levels. Compounds like birth control medications can be active at low part per trillion levels.”

Right now Brooks is trying to sort out what effects drugs are having on fish.

Hormones like estrogen appear to be feminizing male fish. Antidepressants might change how fish behave. And no one’s sure how drugs might be affecting our drinking water.

Brooks says one thing that can be done at the treatment plant is adding reverse osmosis filters. But they’re expensive.

Brooks says there’s not much we can do about excreting drugs, but at the very least we shouldn’t be flushing drugs down the drain.

For The Environment Report, I’m Rebecca Williams.

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Using Honey for Healing

  • Stores in Alandejani's hometown of Ottawa have had an increase in sales of manuka honey after the study was reported (Photo by Karen Kelly)

According to the Centers for Disease Control, more than 90,000 Americans are diagnosed with an antibiotic-resistant infection each year. Doctors and patients are desperate to find an alternative treatment for these infections. Karen Kelly reports on the possibility of a new approach using a common household ingredient:

Transcript

According to the Centers for Disease Control, more than 90,000 Americans are diagnosed with an antibiotic-resistant infection each year. Doctors and patients are desperate to find an alternative treatment for these infections. Karen Kelly reports on the possibility of a new approach using a common household ingredient:

(sound of teapot and pouring)

A lot of us like to pour a cup of tea with honey when we’re feeling achy and stuffed up.

But researcher Talal Alandejani wondered if honey might be good for more than just soothing a sore throat.

He’s an ear, nose and throat doctor at the University of Ottawa in Canada.
He knew honey had been used on the skin for centuries to kill bacteria in wounds.
And he wondered if there might be a way to use it with his patients.

He treats people with chronic sinus infections that are resistant to antibiotics.

“I thought, what if I could use it in the sinus where we use antibiotics, but we still can’t get rid of the infection. It’s a natural product, it has less side effects and it’s less expensive.”

So, Alandejani chose four different types of honey:
clover and buckwheat honeys, which are common in North America,
Manuka honey, which is grown in New Zealand and sold mostly in health food stores,
and sidr honey from Yemen, which is hard for Americans to find.

He then grew bacteria in petri dishes.
Some were free-floating – the kind killed by antibiotics.
The others are called biofilms – they have a coating that resists medications, and they’re the cause of chronic sinus infections and other diseases.

Alandejani squirted the bacteria with antibiotics in one dish, and honey in the other.

The manuka and sidr honey -along with the medications – killed the free-floating bacteria.
The biofilms, though, were a different story.
The antibiotics didn’t kill them, but the honey did.

In fact, the two foreign honeys killed about 90% of the pseudomonas and 60 to 70% of MRSA bacteria. Both can cause deadly infections.

Alandejani presented his findings at the annual meeting of the American Academy of Oto-laryn-gology, Head and Neck Surgery.

And he was swamped with questions from doctors and sinus patients eager to try it.

“Even the patients in our clinics want us to treat them right now, before even doing the trials or the animal studies. And they’re willing to take the harm of it, if there is any, because their disease is not treated until now.”

Alandejani says the challenge is that the honey has to come in contact with the bacteria – so it would have to be diluted and injected into the sinuses.

Dr. Murray Grossan is an ear, nose, and throat doctor in Santa Monica.
He says the treatment looks promising.

“They do use honey for stomach problems, stomach ulcers and so on, so it probably would be pretty safe to put into the sinus. But unfortunately, we have to go through all sorts of protocol there.”


In the meantime, stores in Alandejani’s hometown of Ottawa have had an increase in sales of manuka honey after the study was reported.

It’s not cheap – manuka honey can cost as much as $50 a jar.

Alandejani says he used the regular manuka honey, nothing especially strong.
And he can’t vouch for it’s effectiveness if you just eat it.

But he’s now trying it on sinuses in animal studies.

And soon, his patients with chronic sinusitus will have their chance to try it as well.

For The Environment Report, I’m Karen Kelly.

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Acupuncture for the Masses

  • Some consumers choose alternative treatments, like acupuncture, because they want a smaller environmental footprint from their medical care. (Photo courtesy of the National Institutes of Health)

Acupuncture has been used as a medical treatment in Asia for thousands of years. It’s catching on in this country, but it can be pricey. Now a new kind of low-cost acupuncture clinic is springing up with a goal of bringing acupuncture to the masses. As Ann Dornfeld reports, this new type of clinic might just be healthy for the planet, too:

Transcript

Acupuncture has been used as a medical treatment in Asia for thousands of years. It’s catching on in this country, but it can be pricey. Now a new kind of low-cost acupuncture clinic is springing up with a goal of bringing acupuncture to the masses. As Ann Dornfeld reports, this new type of clinic might just be healthy for the planet, too:

Esther “Little Dove” John is lying on a treatment table with the same blissful smile as someone who’s just had a massage. Except she’s about to get stuck with a couple dozen needles.

“Anything in particular you want to focus on today?”

“I have tingling in my fingers and numbness in the toes.”

Acupuncturist Jordan Van Voast taps fine steel needles into John’s hands; then her stomach, her legs, and her ears.

“All of a sudden, my body just relaxed.”

This would be a typical scene from an acupuncture clinic. Except the recliner that serves as John’s treatment table is just one in a circle of ten. It’s a treatment model called “community acupuncture.”

Jacque Larrainzar is getting treated in a chair across from John. She used to go to a standard acupuncture clinic with private rooms. But she prefers the communal style of this Seattle clinic, called – wait for it – “CommuniChi.”

“The feeling is very different. Seeing other people relax and just giving themselves the opportunity to heal is, in itself– I think it helps you to focus on yourself and heal.”

Community acupuncture clinics are designed to make acupuncture affordable to people at all income levels, regardless of insurance. Patients pay a sliding scale fee – as little as 15 dollars per treatment. It’s 60 dollars or more at a standard acupuncture clinic. Community acupuncture keeps costs down through low overhead: using one treatment room and recliners cuts down on electricity and laundry costs. And CommuniChi co-owner Serena Sundaram says that also means a smaller environmental footprint.

“All of those things are really different even than a regular acupuncture clinic, which is already a smaller footprint than a Western practice.”

You don’t need big, high-tech equipment for acupuncture or even electricity — just a place to lie down and a handful of tiny needles.

Patient Esther “Little Dove” John says she’s glad that acupuncture doesn’t involve pharmaceuticals.

“If I were using the mainstream treatment for my condition, I’d be expelling those chemicals into the environment and the fish would be taking it and the birds would be drinking it.”

Scientists have found high levels of pharmaceuticals in the water downstream from water treatment plants. They’re worried about the effect on fish.

Emily Wong is a physician at the University of Washington Medical Center. She practices Western medicine, but also studied acupuncture. Wong says there’s extensive evidence that acupuncture helps with a lot of health problems where Western medicine falls short, like headaches, back aches, and nausea.

But, she says acupuncture is no panacea. She says some acupuncturists claim to be able to treat conditions like kidney stones without scientific evidence to support their claims.

“I see it as being more similar to, for example, physical therapy as a modality that treats many conditions quite well, and as an alternative to a surgical approach or perhaps a pharmacological approach to some conditions.”

If acupuncture works as well or better than a stay at the hospital or a prescription of drugs, it could have a lot lower impact on the environment. And if the new community clinics bring more people to acupuncture, it’s possible the earth will get a little relief too.

For The Environment Report, I’m Ann Dornfeld.

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